Hepatoprotective effect of hydroalcoholic extract of Vitis vinifera L seeds on paracetamol-induced liver damage in Wistar rats.

Abstract

Vitis vinifera L has been used traditionally in Pakistan, Italy, and Turkey as laxatives. Carminatives are used as drug therapy for many diseases. The study aims to determine the hepatoprotective potential of the hydroalcoholic extract of Vitis viniferaL (EVV) seeds in paracetamol-induced hepatotoxicity in albino rats. The hepatoprotective effect of the hydroalcoholic extractof Vitis vinifera L (EVV) seeds was tested in vivo by assessing the antioxidant parameters, liver enzymes, biochemical parameters, and histopathological examinations. Wistar rats-induced hepatotoxicity with paracetamol treated with Vitis vinifera L seeds at 200 and 400 mg/kg exhibited decrease in in vivo antioxidant parameters, liver enzymes, and biochemical parameters due to the presence of phytoconstituents such asflavonoids, steroids, glycosides, quinine, phenol, and saponin. The histological examinations of liver tissue revealed increased necrosis in untreated animals, whereas the central vein, surrounded by normal cells with good architecture, was observed in EVV-treated animals compared to silymarin-treated groups (25 mg/kg body weight). The scientific findings revealed that the hydroalcoholic extract of Vitis vinifera L. seed possesses hepatoprotective potential.