LC-MS Chemical Profiling of Dichloromethane Fraction of Methanol Extract of Syzygium samarangense Stem Bark

Abstract

Prior studies have demonstrated that Syzygium samarangense possesses antioxidant, antifungal, and anti-inflammatory properties as  well as other advantages. The fruit is widely consumed, yet the medical benefits of the stem bark as an alternative therapeutic option  have not been explored. This research was performed to determine the specific chemicals contained in the dichloromethane fraction of  the methanol extract of this plant. The powdered plant sample was extracted with methanol by maceration and fractionated with  dichloromethane. The resulting dichloromethane fraction was then concentrated, and its chemical constituents were identified using LC- MS based on the Willey and NIST libraries. The findings of this research showed the presence of 40 phytoconstituents in five main classes  of secondary metabolites: phenolics, flavonoids, terpenoids, steroids, and others. This study explains the basic structures, compound  derivatives, biological functions of the compounds identified in F2 with reference to relevant literature. The stem bark of S. samarangense  predominantly contains compounds with significant bioactivity, including antioxidants, antifungal, anti-inflammatory,  anticancer, and antiviral properties. This research offers valuable insight into the groundwork for the utilization of this plant and the  selection of natural and synthetic substances.