A systematic review on the hypoglycemic potentials of mahogany (Swietenia spp.) seeds as antioxidants in the management of Gestational Diabetes Mellitus

Abstract

The prevalence of Gestational Diabetes Mellitus (GDM) has increased worldwide alongside an increase in the prevalence of type 2 diabetes mellitus (T2DM). Indonesia is endowed with a rich biodiversity and medicinal plants, including mahogany. Mahogany seeds contain flavonoids, saponins, and limonoids. Limonoid compounds have been shown to inhibit the production of reactive oxygen species (ROS) through the activation of antioxidant enzymes. This study focuses on a systematic review of the potential of the seeds of Swietenia spp. as an antioxidant in GDM. A systematic literature review of 13 scientific articles comprising 12 original research articles and 1 review article published within the last 7-8 years from various scientific databases was conducted. The original research articles were categorized into in vivo and in vitro studies with respect to the antioxidant activity of Swietenia spp. seeds. The systematic review provided a comprehensive understanding of the potential of mahogany seeds as an antioxidant and its role in the management of GDM.