Evaluation of Clitoria ternatea L. Flower Extract in Preventing Complications of Diabetes Mellitus

Abstract

Flavonoids and anthocyanins can be found in the Clitoria ternatea flower (C. ternatea). It has been demonstrated to lessen oxidative stress and to inhibit both the pancreatic enzyme -amylase and the intestine's -glucosidase. HbA1c is  commonly used to detect glycemic levels, whereas malondialdehyde (MDA) is crucial for determining the potential  risk of lipid peroxidation-related problems. This research assessed C. ternatea flower extract's (CTE) alter on fasting  blood glucose, hemoglobin A1c (HbA1c), and MDA in Wistar rats with diabetes (DM) induced by streptozotocin- nicotinamide (STZ-NA). Thirty-six male Wistar rats were all used in this post-testonly control group experiment and  allocated into six groups: standard control, DM control, DM+4,5 mg/kg acarbose, and DM+150 mg/kg CTE, DM+300  mg/kg CTE, and DM+600 mg/kg CTE, respectively. After 28 days of therapy, fasting blood glucose, HbA1c, and MDA  plasma levels were assessed. DM+600 mg/kg CTE showed the lowest fasting blood glucose levels at 90.43±0.94 mg/dl.  With a p-value of p<0.05, the Kruskal-Wallis test findings for fasting blood glucose and HbA1c levels demonstrated  significant differences between the therapy groups. DM+600 mg/kg CTE showed the lowest levels of MDA of 3.13±0.09  nmol/ml and HbA1c of 26.04±0.13 ng/ml. One-way ANOVA findings for MDA levels had a p-value of p<0.05, indicating a  significant difference between the treatment groups. According to the results, rats with diabetes induced by STZ-NA had  lower fasting blood glucose levels, HbA1c, and MDA after receiving C. ternatea extract. Clitoria ternatea may have the  ability to prevent DM problems.