Natural compounds from endophytes with anti-plasmodial potential: a meta-analysis

Abstract

Malaria is still the world-leading cause of death despite the massive arsenal of available drugs. Endophytes, well-established as sources of bioactive molecules have also demonstrated their ability to produce new anti-plasmodial compounds. This review aimed at highlighting the great potential of endophyte as a source of drugs and drugs tools against Plasmodium falciparum.
Material and method :All paper working on endophyte for their antiplasmodial effect were considered. But, those failing to describe the plant collection, isolation, extract preparation, compounds isolation, clear antiplasmodial testing protocols were not included in this review. Besides, it will put side by side in vitro anti-plasmodial effect and the in-silico drug-like properties, pharmacokinetic and toxicity predictions.
Results :From the above analysis, the compounds from bacterial endophytes were less analyzed in comparison to that from fungi. 117 compounds were reported in the literature. 39, 53, and 54 were the most efficient with IC50 of 0.079 μM, 0.146 μM, and 0.43 μM respectively. They effect were better than that of artemisinin (Compounds 118; IC50=0.8 μM). Regarding the predicted pharmacokinetic and toxicology, compounds 39 is as druggable as Artemisin.
Conclusion:The review set endophytes are a non-negligible source of novel drug and drugs tools against Plasmodium falciparum.