Exploring the Potential Link: Atherosclerosis and Chronic Spontaneous Urticaria: Analyzing Lipid‑Related Atherosclerosis Markers in 203 Patients at a Specialized Urticaria Outpatient Clinic in a Tertiary Center

Abstract

Background: This study investigated the relationship between Chronic spontaneous urticaria and atherogenic dyslipidemia. 

Methods:  The study retrospectively screened 203 patients diagnosed with CSU and 182 healthy controls between January 2017 and January 2024.  We compared the weight of the atherogenic component in the cholesterol components of patients with CSU. The same comparisons  were made in patients and control groups when those with total lipid levels below ≤ 200 mg/dL were selected. 

Results: Atherogenicity  markers such as Atherogenic index of plasma (AIP) (p<0.001), remnant lipoproteins (p<0.001), non-HDL-C (p=0.031), and non-HDL to HDL- C ratio (p=0.043) values were higher in the CSU group compared to the healthy control group. While this situation was similar in the  female gender, statistical significance remained only for AIP (p=0.004) and remnant lipoproteins (p=0.043) among these parameters in  males. While there was statistical significance for AIP (p=0.004) and remnant lipoproteins (p=0.043) in patients with total cholesterol levels  ≤ 200 mg/dL, no significant differences were detected for the markers non-HDL-C (p=0.545) and non-HDL-C to HDL-C (p=0.292).   

Conclusions: Atherogenic lipids may be markers that may able to differentiate patients with the potential to develop CSU.