Is the BNT162b2 Vaccine Still Effective against the Latest Variant: XBB.1.5?

Abstract

Background: The XBB.1.5 sub-variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron now continues to  spread rapidly due to the increased transmission rate as a result of increased affinity of the virus binding over the ACE-2 receptor – a  gained property due to the mutation that occurred in spike protein. 

Aim: The protectivity of BNT162b2 antibodies produced in the serum  of patients is an important parameter for preventing transmission. However, the affinity of the antibodies of patients vaccinated with  BNT162b2 over the latest SARS-CoV-2 variant, XBB.1.5, is not well established. This study aimed to evaluate the efficacy of the BNT162b2  vaccine-induced antibody on XBB.1.5 by comparing the X-ray crystallographic structures and spike protein mutations of BA.5 and XBB.1.5  using in silico methods. 

Materials and Methods: Binding points and binding affinity values of the BNT162b2 antibody with BA.5 and XBB.1.5 spike protein were calculated using ClusPro 2.0 protein–protein docking and Discovery Studio 2021 Client software. Mutations in  the genetic code of the spike protein for SARS-CoV-2 BA.5 and XBB.1.5 sub-variants were screened using the GISAID database. 

Results:  Binding affinity values showed that BNT162b2 had higher negative values in the XBB.1.5 sub-variant than BA.5 at the mutation sites at the  binding region. The results suggested that BNT162b2 may retain its activity despite mutations and conformational changes in the  binding site of the XBB.1.5. 

Conclusion: The findings of this study shed light on the importance and usability of the current BNT162b2  vaccine for XBB.1.5 and future variants of concern.