Regenerative Endodontic Treatment of an Immature Incisor Tooth with a Novel Platelet‑Rich Product: A Five‑Year Follow‑Up Case Report

Abstract

This case report presents a five‑year follow‑up and the management of a necrotic, immature incisor tooth treated by a novel platelet-rich  plasma/platelet extract solution and platelet‑rich fibrin (PRP–PES/PRF) and the restoration by using a stress-reduced direct composite  restoration (SRDC) technique. The patient with a broken maxillary lateral tooth was referred to our clinic. Extra/intra-oral examinations  were within normal limits. The nonvital tooth having an apical lesion and open-apical apex was treated with a regenerative endodontic  treatment procedure (REP), and further root development with continued apical closure was shown in the follow-ups up to 60 months. In  conclusion, the SRDC and PRP–PES/PRF combination can be an opportunity for the teeth requiring post-restoration. In contrast to the  treatment strategy susceptible to weakening or fracturing the patient’s tooth root, the REP approach may lead to a better prognosis for  the patient’s tooth.