The Effect of Rocuronium Priming Dose Based on Actual Versus Corrected Body Weight in Modified Rapid Sequence Intubation

Abstract

Background: Rapid sequence intubation (RSI) is a technique that allows patients to be quickly intubated and have the airway secured. 

Aims: The purpose of this study was to investigate the effect of rocuronium priming and intubation dose calculated according to actual  body weight (ABW) or corrected body weight (CBW) on the neuromuscular block and intubation quality in rapid sequence induction and  intubation (RSII).

Patients and Methods: This prospective randomized, double-blind study was conducted on a total of 60 patients  randomized into two groups using the closed-envelope method between January 2021 and December 2021, with 30 individuals in each  group. In group 1, CBW was used with the formula to calculate the neuromuscular blocking drug (NMBD) dose. The ABW of patients was  used to calculate the NMBD dose in group 2.

Results: The data of 50 female patients who underwent group 1 (CBW, n = 25) and group 2  (ABW, n = 25) were analyzed. Age, weight, height, body mass index (BMI), quality of laryngoscopy, post‑priming side effects, mean arterial  pressure (MAP), and heart rate (HR) values did not differ across the groups. When train‑of‑four (TOF) values, priming and  intubation dose, and laryngoscopy time were compared, a statistically significant difference was found between the two groups of TOF  count (TOF C) 1 (the duration of action).

Conclusion: This study suggests that the application of rocuronium priming and intubation dose  according to CBW in RSII, especially during the pandemic, provided similar intubation conditions as the application according to ABW,  while its shorter duration of action shows that it can be preferred, especially in short-term surgical cases.