The Efficacy and Results of Medical Treatment in Postoperative Ileus

Abstract

Background: Postoperative paralytic ileus refers to the disruption of the normal coordinated propulsive motor activity of the  gastrointestinal system following surgery. Surgery causes inflammation in the muscle walls of organs with an intestinal lumen that, in  turn, leads to a decrease in intestinal motility.

Aim: The aim of this study was to investigate the efficacy of gastrografin, neostigmine, and  their combined administration in patients diagnosed with paralytic ileus in the postoperative period.

Patients and Methods: One- hundred twelve patients were included from January 2017 and November 2019. The retrospective study is involving prolonged  postoperative ileus cases following colorectal surgery. The effect of gastrografin, neostigmine, and gastrografin neostigmine  combination was compared retrospectively in the treatment of prolonged ileus after surgery.

Results: The study covered 112 patients.  Gastrografin was administered to 63 patients; neostigmine was administered to 29, while 20 patients received the combination of the  two. Data pertaining to the comparison of the two groups revealed that patients in the gastrografin group were discharged earlier than  those in the neostigmine group. Further, patients in the combined group had earlier gas and/or stool discharge and were also  discharged from the hospital earlier than those in the neostigmine group.

Conclusion: Gastrografin and combined use of gastrografin  and neostigmine are effective and viable methods for postoperative ileus cases. Gastrografin can safely be used in patients with  anastomoses.