Can Montelukast Sodium be an Alternative Treatment in the Treatment of Interstitial Cystitis?

Abstract

Background: The leukotriene D4 receptors have been detected in human bladder detrusor myocytes, and they can play the role of  interstitial cystitis etiology.

Aim: Our study aims to explain the role of mast cells histologically and immunohistochemically in the  pathogenesis and the effectiveness of montelukast that leukotriene D4 receptor antagonist in the treatment of interstitial cystitis.   

Subjects and Methods: Twenty-four Wistar albino adult female rats were used. Group 1 (n = 8): control (sham) group, Group 2 (n = 8):  interstitial cystitis group, and Group 3 (n = 8): treatment group. Groups 2 and 3 rats were administered 75 mg/kg cyclophosphamide four  times every three days intraperitoneally. The rats in the treatment group were started on montelukast sodium as 10 mg/kg, 1 × 1/ day per  orally after the last administration of cyclophosphamide and were given for 14 days. Mast cells in the bladder tissues were examined  histologically, and the presence of IL-6, 8, VEGF, and TNF alpha was examined immunohistochemically.

Results: Thin transitional  epithelium, loose connective tissue, weak smooth muscle bundles, and signs of chronic inflammation were observed in the interstitial cystitis group. Regenerated transitional epithelium, intact basement membrane, compact lamina propia, thick smooth muscle bundles,  and rare inflammatory cells were observed after the treatment with the montelukast. Mast cells were decreased in bladder tissue after  treatment. IL-6, IL-8, VEGF, and TNF alpha levels were significantly decreased after treatment.

Conclusions: We found that inflammatory mediators were significantly reduced after treatment with montelukast in the interstitial cystitis group. Montelukast can be used as an  effective drug in the treatment of interstitial cystitis.