An Audit of Endometrial Hyperplasias at the Lagos University Teaching Hospital

Abstract

Introduction: There has been much controversy and confusion surrounding the
endometrial hyperplasias stemming from the use of a wide variety of terminologies
and also from the pathophysiologic mechanisms underlying the various entities. The
current classification by the World Health Organization (WHO) published in 2014
clarifies these issues. Objective: The aim of this study, therefore, was to audit and
standardize cases of endometrial hyperplasia diagnosed in our institution from 2007
to 2011. Materials and Methods: The slides and request forms of cases diagnosed
as endometrial hyperplasias at the Department of Anatomic and Molecular Pathology
from January 1, 2007, to December 31, 2011 were retrieved, reviewed, and reported
according to the WHO 2014 classification scheme. Results: Hyperplasia without
atypia accounted for the vast majority of cases (95.5%) and was the most common
in the 5th decade. Concordance rates of 74.5% and 100% were found between
endometrial hyperplasias without atypia and atypical hyperplasias with their previous
diagnoses, respectively. Conclusion: The WHO classification scheme standardizes
and simplifies the terminology used in the diagnosis of endometrial hyperplasias,
while reflecting, at the same time, the current understanding of genetic changes that
provide information necessary for prognostication and treatment.

Keywords: Atypical, complex, endometrial, hyperplasia, nonatypical, simple