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Relationship between Thyroid Hormone levels and Hyperthyroid Signs and symptoms
Abstract
Objective: Assessment of thyrotoxic patients often involves laboratory and clinical evaluation. We have therefore investigated the relationship between the magnitude of hyperthyroid symptoms and thyroid hormone levels in a set of newly diagnosed thyrotoxic patients.
Methods: Fifteen subjects with untreated, newly diagnosed thyrotoxicosis were prospectively studied to investigate the relationship between symptom severity and the degree of hormone elevation. Two standardized symptom rating scales the “Waynes score” (WS) and the “Hyperthyroid symptom score” (HSS) as well as laboratory tests of serum T3, T4 and TSH was employed.
Results: Four (26.6%) subjects were men, while 11 (73.3%) were women. The mean age of subjects was 43.9±13.3 years. 12 (80%) had Graves disease while 3 (20%) had toxic multinodular goiter. All subjects had elevated thyroid hormones and Waynes score but HSS was normal in 6 940%) patients. WS corrected positively with HSS (r=0.66, p<0.05). There was no significant correlation between both parameters and thyroid hormone levels.
Conclusion: Our findings show that none of the symptom rating scales for hyperthyroidism was significantly related to thyroid hormone levels. The Waynes score may however be more reliable than the HSS in the initial assessment of suspected thyrotoxicosis.
KEY WORDS: Hyperthyroidism, symptoms, thyroid hormones
[Nig J Clinical Practice Vol.5(1) 2002: 29-31]
Methods: Fifteen subjects with untreated, newly diagnosed thyrotoxicosis were prospectively studied to investigate the relationship between symptom severity and the degree of hormone elevation. Two standardized symptom rating scales the “Waynes score” (WS) and the “Hyperthyroid symptom score” (HSS) as well as laboratory tests of serum T3, T4 and TSH was employed.
Results: Four (26.6%) subjects were men, while 11 (73.3%) were women. The mean age of subjects was 43.9±13.3 years. 12 (80%) had Graves disease while 3 (20%) had toxic multinodular goiter. All subjects had elevated thyroid hormones and Waynes score but HSS was normal in 6 940%) patients. WS corrected positively with HSS (r=0.66, p<0.05). There was no significant correlation between both parameters and thyroid hormone levels.
Conclusion: Our findings show that none of the symptom rating scales for hyperthyroidism was significantly related to thyroid hormone levels. The Waynes score may however be more reliable than the HSS in the initial assessment of suspected thyrotoxicosis.
KEY WORDS: Hyperthyroidism, symptoms, thyroid hormones
[Nig J Clinical Practice Vol.5(1) 2002: 29-31]
