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Pathological study of diabetic Nephropathy based on renal Biopsy: A prospective Study
Abstract
Background of the Study, Aims & Objectives: There are few studies on the histological patterns of diabetic nephropathy in this environment on a prospective basis. This study is important because of the increasing prevalence of diabetes mellitus and diabetic nephropathy in this environment. The aim of this study was to show the renal histological features among Nigerian diabetics.
Subjects, Method and Materials: Fifty-five diabetics with proteinuria had their medical records reviewed. Tissues from renal biopsies were processed and examined for histological lesions. Quantitative data was analyzed with the student's t-test and X2 analysis.
Results: Fifty-five patients, 35 males and 20 females, formed the study group out of the 138 diabetics screened (77 males and 61 females); majority 47 (85%) had type 2 while eight (15%) had type 1 diabetes mellitus. The frequency of occurrence of clinical diabetic nephropathy was 39.9%. Twenty-five (45.5%) of the patients had biopsy specimens with varying degrees of glomerular obsolescence. The frequency of occurrence of nodular and diffuse glomerulosclerosis was 20% and 98.1% respectively. Armani-Ebstein lesion was rare among the patients studied.
Conclusion: There is high prevalence of diabetic nephropathy in the study population. The frequency of occurrence of nodular and diffuse glomerulosclerosis among the diabetics studied was 20% and 98.1% respectively.
KEY WORDS: Diabetes Nephropathy, Renal Biopsy, Pathological Study.
[Nig J Clinical Practice Vol.5(1) 2002: 5-9]
Subjects, Method and Materials: Fifty-five diabetics with proteinuria had their medical records reviewed. Tissues from renal biopsies were processed and examined for histological lesions. Quantitative data was analyzed with the student's t-test and X2 analysis.
Results: Fifty-five patients, 35 males and 20 females, formed the study group out of the 138 diabetics screened (77 males and 61 females); majority 47 (85%) had type 2 while eight (15%) had type 1 diabetes mellitus. The frequency of occurrence of clinical diabetic nephropathy was 39.9%. Twenty-five (45.5%) of the patients had biopsy specimens with varying degrees of glomerular obsolescence. The frequency of occurrence of nodular and diffuse glomerulosclerosis was 20% and 98.1% respectively. Armani-Ebstein lesion was rare among the patients studied.
Conclusion: There is high prevalence of diabetic nephropathy in the study population. The frequency of occurrence of nodular and diffuse glomerulosclerosis among the diabetics studied was 20% and 98.1% respectively.
KEY WORDS: Diabetes Nephropathy, Renal Biopsy, Pathological Study.
[Nig J Clinical Practice Vol.5(1) 2002: 5-9]
