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Apr 30, 2021Keywords:
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Main Article Content
Assessment of lipid, haematoloical and coagulation parameters following oral administration of Ficus capensis in male albino rats
Abstract
Abnormal blood coagulation and hyperlipidemia remain the main cause of cardiovascular diseases. Despite the numerous and long-term use of Ficus Capensis as a medicinal plant in South East Nigeria, there is limited information on its effect on coagulation parameters. This study is aimed at evaluating the effects of oral administration of methanol extract of F. Capensis on lipid, hematological and coagulation parameters in male albino rats. A total of twenty four (24) male Wister albino rats weighing 180 – 200g were divided into 4 groups of 6 rats each. The test groups (2, 3 and 4) received orally graded doses (100, 200 and 400mg/kg body weight) of methanol extract of Ficus Capensis for 4 weeks, while group 1 (control) was given 0.5ml normal saline for the same period. At the end of the experimental period, animals were sacrificed; blood sample was collected by cardiac puncture for the estimation of selected biochemical parameters. The results showed a significant increase (P<0.05) in body weight, haematological parameters tested, high density lipoprotein, and prolongation of clotting time (CT), prothrombin time (PT) and activated partial thromboplastin time (a PTT) when compared with the control group. A significant (P<0.05) decrease in the concentration of total cholesterol, triglyceride, low density lipoprotein and very low-density lipoprotein was also observed. This study has demonstrated a dose related prolongation of PT, APTT, CT, decrease in lipid and increase in haematological parameters by methanol extract Ficus Capensis which may be beneficial in the management
