Effect of IL-1β and IL-1RN polymorphisms in carcinogenesis of the gastric mucosa in patients infected with Helicobacter pylori in Algeria

Abstract

Background: Infection with Helicobacter pylori is considered a potential risk of developing gastric cancer in association with contributing host genetic factor. IL-1β and IL-1RN polymorphisms appear to maintain and promote Helicobacter pylori infection and to stimulate neoplastic growth of the gastric mucosa.

Objective and methods: In order to elucidate the effect of these polymorphisms in combination with gastric cancer in a population from northwestern Algeria, a case-control study was carried out on 79 patients infected with H. pylori with chronic atrophic gastritis and/or gastric carcinoma, and 32 subjects were recruited as casecontrol. IL-1β-31 bi-allelic and IL-1β-511 bi-allelic polymorphisms and IL 1RN penta-allelic were genotyped.

Results: IL-1β-31C was associated with an increased risk of developing gastric carcinoma (OR4.614 [1.4314.81], p = 0.01). However, IL-1RN2 heterozygous allele type was significantly associated with chronic atrophic gastritis (OR4.2 [1.233.61], p = 0.022). IL-1β-511T was associated with an increased risk of development of chronic atrophic gastritis (OR4.286 [1.5411.89], p = 0.005).

Conclusion: IL-1β and IL-1RN polymorphisms associated with H. pylori infectioncontribute to the development of chronic atrophic gastritis and gastric carcinomas in an Algerian population. The alleles IL-1β-31C and IL-1RN were associated with an increased risk of developing gastric carcinoma, and IL-1β-511T with an increased risk of developing chronic atrophic gastritis with no significant association of developing gastric carcinoma.

Keywords: gastric mucosa; Helicobacter pylori; IL-1β; IL-1RN