Article Sidebar
Published:
Dec 2, 2023DOI:
10.4314/jdan.v13i2.1Keywords:
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Manuscripts are accepted for publication with the understanding that no substantial part has been, or will be published elsewhere. By submitting a manuscript, the authors agree that the copyright is transferred to the publisher if and when the articles, including reprints, photographic reproduction and translation are accepted for publication. Copyright owner is the Dietitians Association of Nigeria. An abstract at the beginning of an article may be reproduced without specific permission provided the original citation is provided. Statements made and opinions expressed in letters to the Editor, Editorials, Presidential address, book reviews and other special articles appearing in this journal are views of the author(s) and do not necessarily reflect the position of the Journal or the Association.
Main Article Content
Effects of raw and boiled garlic extract on body weight, fasting blood glucose, and lipid profile of alloxan induced adult male Wistar rats
Abstract
Background: The burden of diabetes is high and rising in every country, fueled by the global rise in the prevalence of obesity and unhealthy lifestyles.
Objective: This study assessed the effects of raw and boiled garlic extract on body weight, fasting blood glucose, and lipid profile of alloxan-induced adult male Wistar rats.
Materials and methods: Fresh garlic bulbs were peeled, washed, and drained after which they were divided into 2 equal portions. The rats were grouped into seven based on body weight with a difference not more than ±5g per group. Each group was labeled A, B, C, D, E, F, and G with 4 rats in each group. Rats in groups A, B, and C were administered 10mg, 20mg and 30mg of raw garlic extract per kilogram body weight, respectively while rats in groups D, E, and F were administered 10mg, 20mg, and 30mg of cooked garlic extract per kilogram body weight respectively then group G rats (control; induced but not treated) were administered with 10mg of plain water per kilogram body weight. All statistical analysis was carried out using IBM SPSS statistical software, version 21. All values obtained were expressed as mean and standard deviation. Paired sample t-test was used to compare baseline and end values. Differences in mean were considered significant at P <0.05.
Results: There was a significant (P <0.05) decrease in the fasting blood glucose level of the rats administered the experimental diets. A significant (P <0.05) decrease in body weight was observed in rats fed the experimental diets while the weight of the control group increased significantly. The total cholesterol and triglyceride levels of all the groups increased, however, the control had the highest (38.56% & 40.45%) percentage increase (P <0.05).
Conclusion: Garlic extract has a significant effect in reducing body weight and blood glucose levels.
