The effect of Low-dose Gamma Radiation on the Bio-chemical Stability of some Intravenous Fluids

Abstract

Low-dose gamma radiation has been applied to intravenous fluids to enhance the sterility assurance levels. This study was undertaken to determine the stability of gamma irradiated 2.5 % dextrose, 2.5 % dextrose in saline, Ringers lactate and Gastrointestinal replacement fluid at doses of 0, 2, 4, 6, 8, 10 and 20 kGy. Parameters such as pH, dextrose and lactate concentration, pyrogen test and concentration of ions such as Na+, K+, Ca2+, and Cl- were investigated. There was considerable stability for the various parameters of the intravenous fluids after irradiation. Although there were slight variations after irradiation, the concentration of most of the mineral elements were within the normal factory range at doses below 8 kGy. The pH at doses below 8 kGy was fairly stable. The formation of pyrogen was minimal since all the fluids produced temperature rises less than the threshold value of 1.15 0C.


Journal of Applied Science and Technology (JAST), Vol. 4, Nos. 1 & 2, 1999, pp. 24 – 30