Association of serum fetuin-A and fetuin-A gene polymorphism in relation to mineral and bone disorders in patients with chronic kidney disease

Abstract

Disorders of bone and mineral metabolism contribute to an increased prevalence of vascular calcification (VC) with its adverse clinical outcomes in patients with chronic kidney disease (CKD). The pathogenesis of VC is not fully understood. Fetuin-A is one of the inhibitors of calcification whose level is lowered in patients with CKD. In addition fetuin-A 256Ser/Ser (allele G) might affect serum fetuin-A levels. The aim of this work was to study the association between

Keywords: Chronic kidney disease; Fetuin-A; Fetuin-A gene; Vascular calcification; Bone mineral disease