Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population

Abstract

Rheumatoid arthritis (RA) is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions. Both genetic and environmental factors, with unknown etiology, play important roles in this disease pathogenesis. Recently, TRAF1/C5
(Tumor Necrosis Factor Receptor-Associated Factor 1/Complement Component 5) polymorphism associated with increased risk for RA has been studied in different populations worldwide, and inconsistent results have been obtained. rs10818488 allele is located on TRAF1/C5 intergenic
region, and has been predicted to be functional. A total of 100 sex- and age-matched people including RA patients (n= 50) and healthy individuals (n= 50) from Iran have been entered in this study and genotyped for rs10818488 (A/G) polymorphism, using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). In our study, rs10818488 allele was not associated with risk for RA in Iranian population (p> 0.05, OR = 1.27, 95% CI= 0.72–2.23). Results revealed that this allele might be population-specific and not to be associated with their corresponding gene pool. However, further analyses are required to clarify other RA-associated markers in our community.