ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population

Abstract

Background: The Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1).
Aim: To investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India.
Methods: In the present study, we have collected CKD patients (n= 147) and control subjects (n= 211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers.
Results: The DD genotype is associated with the female population (OR-CI = 2.40 (1.05–5.51), p= 0.04) as compared to the male population (OR-CI = 0.75 (0.37–1.51), p= 0.42). Further, we found the over representation of ‘‘I’’ – allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) – 0.58 (0.32–1.04), p= 0.07] which suggests its protective role in male population.
Conclusion: The DD genotype of ACE is associated with CKD in south India.

Keywords: Case control study; ACE I/D polymorphism; Chronic Kidney Disease; HWE