Soluble receptor for advanced glycation end products (sRAGE) and carotid intima-media thickness (CIMT) in type 1 diabetes Mellitus: Possible association with diabetic vascular complications

Abstract

Background: Advanced glycation end products (AGEs) are a heterogeneous and complex group of biochemical compounds, resulting from nonenzymatic glycation and oxidation of protein, nucleic acids, and lipids.
Aim of the study: To assess sRAGE and CIMT in patients with T1DM and their relation to glycemic control and diabetic vascular complications.
Patients & methods: This study included 60 patients with mean age of 14.4 ±3.4 years. They were subdivided into complicated and non complicated groups according to the presence of microvascular complications. Thirty age and sex matched controls were included. Patients with disease duration less than 5 years, connective tissue disease, liver dysfunction, or apparent cardiovascular disease and those on lipid lowering agents were excluded. Laboratory investigations included; HbA1c%, urinary albumin excretion (UAE), fasting lipid profile and sRAGE. Mean CIMT was measured by dopplex ultrasound.

Keywords: Type 1 diabetes mellitus; CIMT; sRAGE; Vasculopathy