Clinical study of Loratadine Tablet combined with Mometasone Furoate nasal spray combined with acupoint application of traditional Chinese Medicine in the treatment of allergic Rhinitis

Abstract

Background: Allergic Rhinitis (AR) is a common variable of immune responses, affecting nearly 50 crores of people worldwide. Therefore,  this study addresses both Western and traditional Chinese medicinal practices to combine and mediate a potent result in  treating AR patients. 

Objective: To achieve a sustainable and long-term impact on the treatment of Allergic Rhinities, a combination of  Western medicines like synthetic corticosteroids and non-sedative antihistamines, along with the traditional Chinese medicine acupoint  herbal patching, has been implemented. 

Methods: A total of 782 patients were included in this study. They were randomly divided into  four groups, maintaining approximately 1:1:1:1. The first group of patients was treated with Loratadine Tablet 10 mg and Mometasone  furoate NS 200 micron (administered once in the morning at waking up and on an empty stomach for 15 days) with placebo traditional  Chinese medicine. In contrast, the second group of patients received the traditional Chinese medicine acupoint herbal patching with  placebo tablets (Vitamin C, 100 mg). Now, the third group was the integrated treatment group, where the patients received both  treatments, and the fourth group received only the placebos for both treatment procedures. 

Results: Different scales were employed to  examine the different symptoms of AR, like the Visual Analog Scale (VAS), Total Nasal Symptom Score (TNSS), Total Symptom Score (TSS),  etc. In order to assess the histological effects of allergic reactions in patients with AR (Allergic Rhinitis), a randomized blood testing  approach was employed. The collected data was subjected to statistical analysis using SPSS 17.0 software. Continuous and normally  distributed data were evaluated using the mean ± standard deviation (x–±s) measurement. Additionally, geometric mean and standard  deviation, ANOVA, and Dunnett's test were performed to identify any potential multiple comparisons. Finally, a Chi-square test was  employed to summarize the data findings. 

Conclusion: The study is a great success in achieving its result on the AR patients. However, to  come with a definite sustainable result, the time of the study needs to be increased by at least a year so that the effectiveness of this  treatment on the changing seasons can be observed and thus statistically analyzed.