Therapeutic effect of emergency stent surgery combined with intravenous thrombolysis on patients with acute ischemic stroke and its influence on their quality of life

Abstract

Abstract
Objective: Ischemic strokes can lead to severe cerebral infarctions with serious complications, as well as cause high disability and mortality rates, which cause a significant burden on the medical field. As of now, there is no permanent therapy for ischemic strokes. So there is a need to find a permanent solution for this complication. Therefore, the present study was to examine whether emergency stent surgery along with intravenous thrombolysis enhanced the health status of patients with acute stroke and ischemia.
Methods: In the current study, 106 patients with acute ischemic stroke hospitalized between November 2019 and November 2020 were randomly allocated to two groups, 53 cases in each study group and control group. The control group was treated with drug thrombolysis, while the study group underwent emergency stent surgery based on drug thrombolysis. The hemodynamic alterations, NIHSS score, Barthel score, and MRS score before and after therapy were evaluated among the two groups at 1 day, 7 days, and 14 days after the therapy. The hemodynamic alterations, NIHSS score, Barthel score, and MRS score before and after therapy were evaluated among the 2 groups at various intervals, 1 day, 7 days, and 14 days after the therapy. The serum cytokine levels of patients before and after treatment were compared, and the incidence of related complications was compared among the tested groups.
Results: Following treatment, both groups' Qmean and Vmean increased considerably, while their levels of R, DR, LBV, and HBV reduced significantly (P<0.05), with the index changes in the test group being more significant than the control group (P<0.05). The patients' NIHSS and MRS scores dropped after therapy, whereas their Barthel score increased (P<0.05). The study group's NIHSS and MRS scores were lower than the control group's at T1, T2, and T3 after treatment, whereas the control group's Barthel score was higher (P< 0.05). The serum SOD levels of the two groups of patients developed after treatment, Chemerin, BNP, angii, IL-6, TNF-α and MDA levels decreased (P<0.05). The level of factor alterations was increased in the tested group as compared to the control group (P<0.05). Complications were less common in the study group as compared to the control group (P<0.05).
Conclusion: The result revealed that emergency stent surgery coupled with drug thrombolysis was more effective than drug thrombolysis alone, with lower complication rates, improved safety, and more successful practical applications. [Ethiop. J. Health Dev. 2022; 36(2) 163-170]
Key words: Emergency stent surgery; Intravenous thrombolysis; Acute ischemic stroke