Clinical effect of continuous nursing combined with total glucosides of paeony on rheumatoid arthritis

Abstract

Abstract
Background: The dried root of Paeonia lactiflora has been used to treat arthritis and diseases like hepatitis in countries like Japan, Korea, and China. This practice of treatment with plant roots is ancient and has been used for more than 1200 years. Water or ethanolic extract of the plant root is known as the glucosides of paeony containing more than 15 different components. Paeony effects mainly through receptors like TGF-beta IL-2 receptors.
Objective: This paper aims to identify the effectiveness of paeony as compared to other medications in the treatment of arthritis.
Method: A systematic review of previously published articles in the past ten years, which were published on rheumatoid arthritis were reviewed and a meta-analysis was performed, which included the paeony treated group and any other medication group used in the treatment of arthritis, using the R statistical software. The results obtained were summarized.
Result: After conducting the meta-analysis, a significant difference was found in the serum level of Erythrocyte Sedimentation rate (ESR) in the glucosidic (GP) and leflunomide (LF) combination or only leflunomide groups (at 95% CI (Confidence interval) GP+LF value -8.67 and only LF value is -3.68), for C reactive protein (at 95% CI) GP+LF value -8.67 and only LF value is -3.04) and rheumatoid factor (at 95% CI GP+LF value -21.81 and only LF value is -8.15).
Conclusion: The analysis indicates that paeony and other medicine combined therapies are more beneficial as compared to therapies which utilize only medication. These finding has been supported by other research findings. Though this study has been conducted using a small sample, it indicates a beneficial outcome for arthritis treatment. These findings may be beneficial in the future and may prove to be a promising treatment for arthritis patients. [Ethiop. J. Health Dev. 2021: 35(4) 375-379]
Keywords: Paeony, rheumatoid arthritis, ESR, CRP, rheumatoid factor