Microwave-assisted synthesis, characterization and antimicrobial activity of copper (II) complex with salicylaldehyde and P-chloroaniline Schiff base

Abstract

Transition Metal Complex of Cu(II) with Schiff base N-salicylidene-4-chloroaniline were synthesized by the use of microwave machine. The mixture of 2-
hydroxybenzaldehyde (salicylaldehyde) 1.04ml, (0.01mol) and 4-chloroaniline 1.27g (0.01mol) were taken in 50ml beaker and mixed thoroughly. The mixture was irradiated in a microwave oven at a power of 160W for 3 minute. The synthesized complex was characterized by solubility test, melting point, infrared spectra, electrical. The solvents used were Dimethyl sulfoxide (DMSO), Dimethyl formamide (DMF), chloroform, ethanol and water. The value obtained in the spectra of the Schiff base showed a band at 1610.2cm^-1 which is assigned to azomethine Ѵ(C=N-), while for the metal complex was found to be 1628.8cm^-1, The shifting of the band of Ѵ(C=N) stretching vibration in the spectra of the Schiff base and metal complex in the region 1610.2cm-¹ to 1628.8cm^-1 indicated that the complexation has taken place. The infrared spectra suggested that the Schiff base behaves as a bidentate ligand. The value of molar conductivity is 25 Ohm^-1cm2mol^-1, which indicated that the complex is electrolyte and the values are in the range of 20.4 – 33.5 Ohm^-1  cm²mol^-1. The Schiff base and its metal(II) complex were tested for antibacterial activity against microorganism using Bacillus cerus and candida albican. The results of the tests indicated moderate antimicrobial activity against the tested organism when compared with the standards (Ciprofloxacin and Fluconazol), and this activity increases by increasing concentration. The Metal Complex showed higher activity than free Ligand
due to chelation.