Proximate analysis, mineral compositions and in-vitro investigation of antidiabetic potential of methanolic leaf extract of Bryophyllum pinnatum

Abstract

Bryophyllum pinnatum has generated a great deal of interest in the scientific world due to its numerous benefits. The proximate content,  mineral composition, and antidiabetic potential of the methanolic leaf extraction were evaluated. The proximate content was evaluated in  a fresh sample to determine the ash, carbohydrate, fat, fiber, protein, and moisture using the method of the Association of Analytical  Chemists (AOAC), and mineral composition was done using an atomic absorption spectrophotometer (AAS). The in vitro method was  used to determine the antidiabetic potential of the leaf by evaluating the inhibitory activity of the leaf extract on alpha-amylase and alpha-glucosidase, respectively. The result shows that Bryophyllum pinnatum contains (0.63 ± 0.05%) ash, (3.72 ± 1.37%) carbohydrate,  (1.13 ± 0.32%) lipid, (3.90 ± 0.26%) fiber, (2.33 ± 0.472%) protein, and (88.08± 1.34%) moisture in fresh samples. The result of the mineral  content revealed that Bryophyllum pinnatum is a good source of minerals such as ‘Fe, Zn, Cu, Mg, Na, K, Ca, Mn, Se, and Co. Furthermore,  the antidiabetic potential of the leaf showed that at various concentrations of the leaf extract, there was an appreciably  level of inhibition on both alpha-amylase and alpha-glucosidase, respectively. This research shows that Bryophyllum pinnatum leaf is a  good source of human nutrition and should be included as a dietary supplement. The leaf can also be used in the treatment or  management of diabetic-related issues.