Evaluation of Cyclin-Dependent Kinase Inhibitor 2A and Hepatocyte Nuclear Factor-1A Gene Polymorphisms in Coronary Artery Diseases

Abstract

Background: Blood lipid-regulating and cell proliferation-regulating genes have both been connected to the development of coronary  artery disease (CAD),we aimed to find the correlation between CDKN2A rs3088440, HNF1A rs55783344CT gene polymorphisms and CAD.  

Methods : One hundred and six participants were subjected to this casecontrol study; case group I: patients with CHD and control group  II: Normal healthy people. Subjects underwent a comprehensive history and physical examination, standard laboratory tests, and  coronary angiograms. CDKN2A rs3088440 and HNF1A rs55783344CT gene polymorphisms was done by (PCR-RFLP).

Results: CT genotype  and CT+TT of HNF1AC were statistically Signiant higher in CAD cases than controls. T allele of HNF1AC was much higher in CAD cases than  controls, with a significant difference between 2 groups. Proportion of those with the CDKN2A GA+AA genotype in the CAD patients  was significantly higher than in the control group. Also, the frequency of the CDKN2A A allele was significantly different between CAD  cases and controls.

Conclusions: Coronary heart disease (CHD) has a complex etiopathogenesis and a multifactorial origin. SNPs are  potential risk factors of CHD. CDKN2A rs3088440 (G>A) and HNF1A rs55783344CT gene polymorphisms be a factor in pathogenesis of  CHD.