Impact of Albumin to Globulin Ratio on The Outcome of Women with Metastatic Breast Cancer

Abstract

Background: Breast cancer is the most frequent malignancy among women all over the globe. The albumin/globulin ratio (AGR) is a simple and cost-effective inflammatory measure that is strongly related with cancer patient prognosis and treatment response.

Aim: To evaluate the prognostic impact of albumin to globulin ratio on the outcome of women with metastatic breast cancer.

Methods: This study is a retrospective analysis of data obtained from sixty female patients diagnosed with metastatic breast cancer and treated in Medical Oncology Department, Zagazig University from January 2015 to December 2017. Several variables were extracted anonymously from patients’ medical records, then were analyzed by applying receiver operating curve (ROC) analysis.

Results: Kaplan Meier survival curves disclosed a 5-year overall survival rate which differed significantly in patients as regard the AGR (p < 0.001), with AGR cut-off value (≤1.1). The 5-year overall survival rate was 35%. On the other side, there were no statistically significant differences between neither AGR and PFS (p = 0.297), nor clinical or pathologic criteria of our studied patients.

Conclusions: Statistically significant correlation was found between AGR and OS; high AGR was associated with prolonged OS. Nevertheless, according to follow-up, a long-term follow-up should be done to assess its prognostic significance for disease-free survival.