Role of Serum Tenascin C in Sepsis

Abstract

Background: Sepsis can range in severity from infection to septic shock, and it can result in multiple organ dysfunction syndrome (MODS) and death. Tenascins are matrix glycoproteins located extracellular that are made during multicellular organism growth and involved in many pathological processes such as tissue damage, tumor angiogenesis metastasis, and inflammation.
Objectives: The aim of this study is to investigate the relationship between serum Tenascin- C levels and sepsis and disease severity in Intensive Care Unit (ICU) patients.
Methods: a case control study, selected participants included 9 apparently healthy subjects, 20 patients with sepsis in ICU and 10 diseased patients without sepsis in ICU. All patients were subjected to full clinical assessments of patients by SOFA score and Lab tests: (CBC, PCT, CRP, LFT&KFT). Tenascin C was measured by ELISA for all participants.
Results: The mean age for all groups is 21-70. There is a high significant increase in CRP, PCT, TLC, urea & creatinine, ALT, and AST in septic patients in relation to that of non-septic patients. Hemoglobin and albumin levels show a significant decrease in septic patients than that in non-septic patients. Sensitivity of tenascin to predict cases with sepsis vs those without sepsis was 75% and specificity was 100%.
Conclusion: In septic patients, the level of serum Tenascin-C can help with early sepsis diagnosis and severity assessment.