Study of Urinary Angiotensinogen as an Indicator of Severity of Diabetic Nephropathy in Type 2 Diabetes

Abstract

Background: Urinary angiotensinogen levels are higher in type 2 diabetes patients with nephropathy, a risk factor for developing renal  and cardiovascular consequences. However, the potential relationship between serum urine angiotensinogen levels and albuminuria (in  terms of its varying concentrations) is not yet established. As a result, we conduct this research.

Methods: Sixtysix adults with type  2diabetes were split into three groups, each of which included 22 people based on their degree of albuminuria, in addition to an ageand  gender-matched control group of 22 healthy volunteers. Routine laboratory tests and urine angiotensinogen were evaluated in the study  groups and correlated to other study parameters.

Results: The current study showed that urine angiotensinogen levels are more  significant in diabetic patients with higher albuminuria levels, and it was also found to be associated with urinary albumin excretion in  diabetic patients with different grades of albuminuria (n = 66, r = 0.666, p<0.001), and it had highly significant validity in the prediction of  albuminuria among individuals with diabetes with sensitivity of 88.6%, specificity of 81.8% and accuracy of 86.4%.

Conclusions: According  to the findings of this study, increased urine angiotensinogen levels were associated with urinary albumin excretion, and elevated urinary  angiotensinogen might be utilized as an effective marker for identifying the degree of albuminuria in diabetic individuals.