Study of The Relation Between Thyroid Function and Metabolic Syndrome in Elderly Patients

Abstract

Background: It is unknown how thyroid hormones, TSH, and other elements of the metabolic syndrome are related to one another. It is possible to investigate and evaluate thyroid function in older adults with and without metabolic syndrome to draw attention to it and look for any connections between thyroid function and the elements of the metabolic syndrome.

Aim: To detect the association of thyroid  Hormones, TSH and components of metabolic syndrome and to evaluate the relationship between thyroid Hormones, TSH and HOMA-IR.  

Methods: This case-control study included 64 elderly subjects with and without metabolic syndrome recruited from outpatient of  Zagazig University hospital, from July 2023 to January 2024. We divided the patients into group (I): 32 elderly healthy individuals without metabolic syndrome matched age and sex served as control group and group (II): 32 elderly patients with metabolic syndrome matched  age and sex served as case group. Thyroid functions tests were measured.

Results: There was a highly statistically significant increase in  TSH in group II compared with group I (p≤0.001). There was statistically significant increase in FT3 in group II compared with group I (p≤0.05). There was statistically significant decrease in FT4 in group II compared with group I (p≤0.05) (Table 3). There was highly statistically significant increase in HOMA-IR in group II compared with group I (p≤0.001). Old age OR 1.79 (CI:1.07-3), smoking OR 1.88 (CI:1.36-2.99), obesity OR 1.07 (CI:1.07-1.26), DM OR 2.8 (CI:1.41- 5.57), HTN OR 1.14 (CI:1.03-1.25) & dyslipidemia OR 1.86 (CI:1.11- 3.12)  were significant risk factors for metabolic syndrome (p≤0.05).

Conclusion: In conclusion, there is a strong association between thyroid  dysfunction and each of metabolic syndrome, and HOMA-IR. Patients with hypothyroidism and subclinical hypothyroidism had an    increased risk of metabolic syndrome.