Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction

Abstract

Background: Acute Myocardial Infarction (AMI) is a well-established cause of morbidity and mortality globally in spite of recent breakthroughs in medical therapy as reperfusion methods, implantable cardioverter-defibrillators, and ventricular assist devices. In myocardial infarction treatment, bone marrow-derived mesenchymal stem cells (BM-MSCs) are expected to demonstrate encouraging results. This study aimed to evaluate the feasible anti-inflammatory and antioxidant role of BM-MSCs infusion in rat model with induced myocardial infarction.
Methods: Rats were randomized into an experimental (AMI) group induced by Adrenaline injection, and a control group. The (AMI) group was divided into 2 subgroups (AMI+PBS) and (AMI+BM-MSCs). The consequences of BM-MSCs infusion on cardiac inflammation and oxidative stress status were observed after 3 days of cell transplantation.
Results: BM-MSCs transplantation reduced the production of the inflammatory cytokine (TNF-a) & oxidative stress markers (MDA), increased anti-inflammatory IL-10 & antioxidant SOD, and improved histological changes in the ischemic myocardium.
Conclusions: This study provides evidence that BM-MCSs suppress oxidative stress and inflammation in cardiac tissue and relatively offer cardiac protection in AMI.