Diagnostic and Prognostic Utility of FFAR2 Gene Expression in Peripheral Blood as a Potential Biomarker for Acute Coronary Syndrome

Abstract

Background: Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality. Presently, there is no convenient marker  that can precisely expect the onset of ACS besides its prognosis. Free fatty acid receptor 2 (FFAR2) has lately been proposed to protect  from heart diseases. The study aimed to assess whether the expression of FFAR2 in peripheral blood is avaluable biomarker for diagnosis  of ACS and prediction of adverse cardiac events (ACEs) among ACS patients with controlled and uncontrolled DM.

Methods: Peripheral  venousleukocytes were collected from 281 patients,133 as control group (Group I) and 148 diabetic patients admitted with ACS (Group II).  GroupII was subdivided into Group II a, 67 ACS patients with controlled blood glucose and Group IIb, 61 ACS patients with  uncontrolled blood glucose. The expression level of FFAR2 was estimated by real time PCR.

Results: FFAR2 expression in ACS patients was  significantly lower than that in the control group. Moreover, the FFAR2 level in ACS with uncontrolled blood glucose was lowerthan  that in ACS patients with controlled blood glucose level. TheROC curve analysisshowedthat FFAR2 level had excellent sensitivity and  moderate specificity to identify patients at riskof having ACE.

Conclusions: FFAR2 could act as a potential biomarker in diagnosis of ACS   and predicting its complications.