In Hospital Prognostic Value of Hepatic Transaminases in Patients with Acute Coronary Syndrome

Abstract

Background: The aspartate aminotransferase (AST) alanine aminotransferase (ALT) ratio, previously considered as a serological parameter for identifying the degree of severity of hepatic fibrosis, is also associated with the prognosis of a variety of diseases, including cardiovascular disease. So, this study aimed to evaluate the value of hepatic transaminases as predictors of in hospital mortality and  complications in patients that were admitted for acute coronary syndrome.

Patients and Methods: This cross-sectional study was carried  out in the Cardiology Department, Faculty of Medicine, Zagazig University and in the Nasser institute for Research and treatment,  Egypt on 200 patients with acute coronary syndrome, patients were divided into three groups; unstable angina (13.5%),  NSTEMI (14.5%) and STEMI (72%).

Results: There was statistically significant difference in Liver enzymes (AST and ALT) between all  groups. Their was significant increase in AST and ALT levels in STEMI group. There was statistically significant increase in Liver enzymes  (AST and ALT) in non-survivors group more than in survivors group. There were statistically significant increase in cardiac enzymes (CK- MB and CK), in non-survivors more than in survivors group. There was no statistical significant difference in Alkaline phosphatase in non- survivors more than in survivors group.

Conclusion: ACS patients had significantly increased hepatic transaminases levels. Moreover,  increased risk of in-hospital all-cause mortality was significantly associated with increased levels of hepatic transaminases.