Etude de l'amidon d'igname (dioscorea cayenensisrotundata) variete kponan en granulation par vobe humide dans la formulation de comprimes a base de chloroqueve diphosphate.

Abstract

The aim of this work was to study the behaviour of yam starch "KPONAN" variety as a diluent on tablets formulation based on chloroquine diphosphate. In a previous study, we had investigated the technological, galenic and biogalenic properties of grains before and after compression compared The to traditional starch on Pharmacopoeia i.e. maize and potato starches. The results have demonstrated that KPONAN starch possess an excellent ability for compression with an average hardness of tablets of 9.4 ± 0.7 Kp, a weight average of 460.2 ± 2.4 mg and a disintegration rate of
1.94%. Disintegration time rates were 8.13 ± 0.4 min and 5.07 ± 0.5 min, respectively, for formulas with and without disintegrant agent. Times of liberation of 50% of chloroquine were 5.0 ± 0.1 min and 3.0 ± 0.1 min, respectively for formulas with and without disintegrant agent. We conclude that KPONAN variety of yam starch can be used successfully in tablet formulation as diluent, binder and disintegrant. It behaved in compression after wet granulation like potato starch.