Antiplasmodial Activity of Bp16524 and Su 2242 Against Plasmodium berghei

Abstract

The effects of two potential drug candidates: BP16524 [a synthetic analogue of cryptolepine] and SU 2242 [an enriched methanolic extract from Enantia chlorantha] on Plasmodium berghei were evaluated in this study. Investigations were performed using suppressive (early infection) and curative (established infection) test procedures. BP16524 showed significant dose dependent suppressive activity but was not effective against established infection. Significant (p<0.05) activity was observed in SU 2242 (both for early and established infections).

Keywords: BP16524, SU 2242, Plasmodium berghei, early and established infections

West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 51-54