Evaluation of analgesic effect of a Ammania baccifera Linn. in mice

Abstract

The analgesic activity of the ethanol extract of Ammania baccifera Linn whole plant (EEAB) was investigated in chemical models of nociception in mice. EEAB at doses of 200, 400 and 600mg/kg i.p produced an inhibition of 20.7%, 43.4% and 72.9%, respectively, of the abdominal writhes induced by acetic acid in mice. In the formalin test, the administration of 200,400 and 600mg/kg i.p had no effects in the first phase (05 min) but produced a dosedependent analgesic effect on the second phase (1540 min) with inhibitions of the licking time of 27.3%, 47.7% and 57.4%, respectively. These observations suggest that Ammania baccifera possesses some analgesic activity.

Keywords: Ammania baccifera, chemical models, nociception, analgesic activity

West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 31-34