Serosurvey of Human T-Lymphotrophic Virus Type 1 Secondary Infection among People Living with Hiv/Aids in Dutse Metropolis, North-Western Nigeriaadf59f

Abstract

Human T-lymphotrophic virus type 1 (HTLV-1) is a causative agent of tropic spastic paraparesis and adult T-cell leukaemia. Evidence is accumulating that HTLV-1 may be responsible for some degree of subclinical immune suppression that may result in an increased rate of HIV. Sixty (60) people living with HIV/AIDS consisting of 20 males and 40 females were recruited in this study. HIV diagnosis was confirmed using Nigerian National Serial Algorithm for HIV test. ELISA technique was used for the detection of HTLV-1 IgG and IgM antibodies, and Cyflow Partec was used for CD4 count. The prevalence of HTLV-1 IgG and IgM antibodies among HIV subjects was 15% and 6.6% respectively. Male patients had a percentage prevalence of 4(6.6%) and female 5(8.3%) of IgG antibodies. IgM antibodies prevalence was 2(3.3%) for male and female each respectively. CD4 Counts of the HIV subjects were evaluated, which revealed that patients with counts 0-200 cells/µl tested negative to HTLV-1 IgG and IgM antibodies. Conclusion: The percentage prevalence recorded in this study shows that HTLV-1 infection is relatively high compared to the previous studies, even though limited information was obtained in relation to HIV/HTLV-1 co-infection in this study area.