Comparative Study and Analysis of Clotting Profiles Between Covid-19 And Non-Covid-19 Patients In Barau Dikko Teaching Hospital, Kaduna

Abstract

Coronavirus disease 2019 (COVID-19) is associated with coagulation abnormalities—disordered hemostasis and high thrombotic risk. The aim of the study was to compare and analyze the clotting profiles between COVID-19 and non-COVID-19 patients in Barau Dikko Teaching Hospital, Kaduna. Conventional coagulation tests such as Activated Partial Thromboplastin Time (APTT), Prothrombin Time (PT), and International Normalized Ratio (INR) were used to determine the coagulation profiles of the respondents. Fifty (50) samples were collected for the tests. Out of these, 25 were positive for COVID-19. The age group 61–70 had the highest percentage of positive cases (40%), while the age group 41–50 had the least percentage of positive cases (4%). Regarding gender, males had a higher number of positive cases (15) than their female counterparts (10). All epidemiological and clinical data were collected, analyzed, and comparative results were carried out. A history of previous diseases was more prevalent among COVID-19 patients compared to non-COVID-19 patients. The clinical characteristics between COVID-19 and non-COVID-19 patients showed similarities in body temperature, catarrh, headache, sore throat, and sputum; however, the presence of a heavy cough was observed exclusively among COVID-19 patients. The clinical laboratory results showed a significant difference (p < 0.05) and positive correlations among PT (0.17), APTT (0.12), and INR (0.08) between COVID-19 and non-COVID-19 patients. These findings suggest the need for further research in this area to better understand the clinical manifestations of the COVID-19 virus among patients.