Article Sidebar
Published:
Jan 20, 2014DOI:
10.4314/tjpr.v12i6.2Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Design Optimization and Evaluation of Gastric Floating Matrix Tablet of Glipizide
Abstract
Purpose: To formulate an optimized gastric floating drug delivery system (GFDDS) containing glipizide with carbomers and cellulosic polymers.
Method: Central composite design (CCD) was employed in formulating the GFDDS using hydroxypropyl methylcellulose K4M (HPMC K4M) (A) and Carbopol 934P (CP934P) (B), as independent variables. Floating lag time (FLT), total floating time (TFT) and time required to release 50 % of the drug (T50) were selected as dependent variables. The dissolution data obtained were fitted to various release models and the floating profiles of the formulations analyzed.
Results: HPMC K4M loading clearly enhanced floating properties while CP934P showed negative effect on floating properties but was helpful in controlling drug release. The quadratic mathematical model developed was used to predict optimum formulations. The computer optimization process, contour plots and response surface plots predicted the concentration of independent variables A and B to be 47.32 and 8.4 mg, respectively, for maximum TFT and T50 at the same time for least FLT. Predicted concentration of independent variables showed the same results experimentally, with -0.75 - 1.47 percentage errors.
Conclusion: CCD demonstrated the role of the derived equations, contour plots and response surface plots in predicting the values of independent variables for the preparation and optimization of glipizide gastric floating matrix tablet.
Keywords: Effervescent, Floating tablet, Design of Experiment, Release kinetics, Central composite design, Optimization.
