Article Sidebar
Published:
Jun 25, 2013DOI:
10.4314/tjpr.v12i3.4Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Formulation and Evaluation of Spray-Dried Esomeprazole Magnesium Microspheres
Abstract
Purpose: To prepare and evaluate in vitro mucoadhesive esomeprazole magnesium microspheres for the treatment of Zollinger Ellison syndrome.
Methods: The microspheres were prepared by spray drying technique using locust bean and xanthan gums as polymers. Esomeprazole magnesium was entrapped in the microspheres at various polymer/cross-linking ratios. Glutaraldehyde was used to cross-link the gums. The microspheres were
evaluated for their micromeritic properties and in vitro release. as well as by Fourier transform infrared (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).
Results: The microspheres were discrete, spherical, and showed good drug entrapment efficiency (60.5 - 92.3 %). FTIR and DSC results indicate that the drug was compatible with the polymers used. Amongst all the formulations, F6 (drug:locust bean gum:xanthan gum, 1:2:2) showed the most suitable sustained release properties with 99.8 % of drug released at the end of 12 h.
Conclusion: Microspheres prepared using locust bean and xanthan gums can be used as a sustained release delivery system for esomeprazole magnesium.
Keywords: Spray drying, Microspheres, Esomeprazole magnesium, Sustained release
