Article Sidebar
Published:
May 9, 2013Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Protective Effect of Cinnamomum tamala Extract on Gentamicin-Induced Nephrotic Damage in Rabbits
Abstract
Purpose: To investigate the reno-protective properties of Cinnamomum tamala against gentamicininduced nephrotoxicity in rabbits.
Methods: Rabbits were randomly divided into four groups (n = 6) including Group-1 (normal saline), Group-2 (gentamicin, 80 mg/kg/day), Group-3 (C. tamala, 200 mg/kg/day) and Group-4 (gentamicin, 80 mg/kg/day and C. tamala, 200 mg/kg/day). Body weight, blood urea nitrogen, serum creatinine, creatinine clearance, serum uric acid, urinary volume and urinary protein excretion were measured followed by histological examination.
Results: Gentamicin-treated animals showed significant renal damage as indicated by rise in blood urea nitrogen (54.18 ± 2.60 mg/dl), serum creatinine (4.02 ± 0.14 mg/dl), serum uric acid (2.34 ± 0.12 mg/dl), urinary proteins (3.86 ± 0.32 mg/dl) and decrease in creatinine clearance (0.76 ± 0.09ml/min), urinary volume (126.00 ± 9.09 ml) and body weight (10.80 ± 1.09 %). However, animals treated with gentamicin and C. tamala significantly protected rabbit kidney from structural and functional changes associated with gentamicin.
Conclusion: Based on the findings, it is apparent that concurrent administration of 200 mg/kg/day of C. tamala leaf extract and gentamicin effectively prevented gentamicin-induced renal damage.
Keywords: Cinnamomum tamala, Renal protection, Gentamicin, Renal damage
