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Published:
Feb 25, 2013DOI:
10.4314/tjpr.v11i6.9Keywords:
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Main Article Content
Comparison of Weibull and Probit Analysis in Toxicity Testing of Hunteria umbellata K Schum (Apocynaceae) Extract in Mice
Abstract
Purpose; Hunteria umbellata has been found to have therapeutic potentials in the treatments of diseases such as yaws, peptic ulcers, diabetes, piles and infertility in Nigeria; hence, the statistical analysis on the determination of acute toxicity of Hunteria umbellata was carried out in mice.
Methods; Data on the acute toxicity studies of the seed extract of Hunteria umbellata administered via the intraperitoneal route was analyzed using the two-parameter Weibull model.
Results; The median lethal dose (LD50) was 1.61 g/kg of body weight. This result falls in the neighbourhood of the median lethal dose earlier obtained in previous reports.
Conclusion; The results show that Hunteria umbellata may be slightly toxic when administered intraperitoneally.
Keywords: Hunteria umbellata, Weibull model, Acute toxicity, Median lethal dose (LD50).
