Article Sidebar
DOI:
10.4314/tjpr.v11i4.6Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Formulation and Characterization of Sustained Release Floating Microballoons of Metformin Hydrochloride
Abstract
Purpose: To formulate sustained release gastroretentive microballoons of metformin hydrochloride with the objective of improving its bioavailability.
Methods: Microballoons of metformin hydrochloride were formulated by solvent evaporation and diffusion method using varying mixtures of hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC) polymers. The balloons were characterized for particle size, surface morphology, incorporation efficiency, floating behavior and in vitro drug release.
Results: The mean particle size of the formulated microballoons was in the range of 34.2 ± 4.7 to 95.7 ± 2.2 μm. Incorporation efficiencies of over 83.8 ± 0.9 % were achieved for the optimized formulations. Most of the formulations were buoyant with maximum buoyancy of 81.4 ± 2.0 % for > 12 h, showing good floating behavior of microballoons. Release kinetic data showed best fit to the Higuchi model, indicating that diffusion was the predominant mechanism of drug release.
Conclusion: Microballoons is a potential suitable delivery system for sustained release of metformin hydrochloride with improved bioavailability when compared with conventional dosage forms of the drug.
Keywords: Gastroretentive drug delivery system (GDDS), Solvent evaporation and diffusion method, Higuchi, Microballoons, Metformin hydrochloride
