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Development of Ultraviolet Spectrophotometric Method for Analysis of Lornoxicam in Solid Dosage Forms
Abstract
Purpose: An ultraviolet spectrophotometric system was developed and validated for the quantitative determination of lornoxicam in solid dosage forms.
Methods: Lornoxicam was dissolved in 0.01M NaOH and analysed using ultraviolet (UV) spectrophotometry. Various analytical parameters such as linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization (ICH) guidelines.
Results: Absorbance maximum in 0.01M NaOH was 377 nm. Beer’s law was obeyed over the concentration range of 2 - 20 mg/ml with a correlation coefficient (r2) value of 0.999. Percent range of error was 0.344 and 0.261 at 0.05 and. 0.01 confidence limits, respectively. Intra- and inter-day precision (% RSD) at different concentration levels were < 2 %, indicating that the proposed derivative spectrophotometric method is highly reproducible during one run and between different runs; LOD and LOQ were 0.105 and 0.318 mg/ml, respectively signifying that it can be adopted for routine quality testing. Mean recovery was 100.82 % for tablets. Low values of % RSD indicate the reliability of the proposed method
Conclusion: The proposed method is highly sensitive, precise, accurate, cost-effective, reliable and rapid for the estimation of lornoxicam in solid dosage forms.
Keywords: Lornoxicam, UV Spectrophotometry, Quantitative determination, Solid dosage forms.
