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Antiprotozoal Activity of α,β-Unsaturated δ-Lactones: Promising Compounds for the Development of New Therapeutic Alternatives
Abstract
The parasite resistance and side effects of drugs used to treat protozoal diseases have led to the search for new therapies, both natural and synthetic. Studies have shown that various α,β-unsaturated δ-lactones displayed high antiprotozoal activity and thus are promising compounds for new drug discovery and development. These compounds and their activity are examined in this review.
Keywords: Lactones, Pyrones, Antiparasitic, Antiprotozoal, Leishmania, Malaria, Chagas, Plasmodium falciparum, Tripanosoma cruzi.
