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Absence of Mutagenicity in Three Nigerian Medicinal Plants - Bidens pilosa, Cleistopholis paterns and Tetrapleura tetraptera
Abstract
Methods: In the in vitro Ames test, Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and Escherichia coli WP2uvrA were used with or without metabolic activation by S9 mix. The highest concentration of B. pilosa, C. paterns, and T. tetraptera for the Ames test was established at 5000 ìg/plate.
Results: B. pilosa, C. paterns, and T. tetraptera did not cause any increase in the number of his+ revertant colonies compared to the negative control values obtained from S. typhimurium and E. coli WP2uvrA strains, with or without the addition of S9 mixtures. The results indicated that these plants are non-mutagenic to all the five S. typhimurium and E. coli test strains in the presence and absence of metabolic activation.
Conclusion: B. pilosa, C. paterns, and T. tetraptera showed negative results in the bacterial reverse mutation test, suggesting that it is potentially safe to use them as medicinal plant supplements even at
high doses.
