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The Effect of Chemical and Physical Enhancers on Trolamine Salicylate Permeation through Rat Skin
Abstract
Methods: Trolamine salicylate permeability parameters through rat skin were evaluated with and without chemical enhancers - Transcutol, eucalyptus oil, oleic acid and sodium lauryl sulfate – using the permeability cell technique.
Results: The main barrier for trolamine salicylate permeability was the epidermis layer of the skin. Also, partitioning from the aqueous donor phase into the skin was the rate-limiting step for drug flux. Transcutol and eucalyptus oil were the most effective enhancers as they increased flux 11-fold. Sodium lauryl sulfate disrupted the lipid structure of the skin and thus increased diffusion coefficient 3-fold. Supersaturation technique did not increase flux. Propylene glycol in cosolvent system increased drug solubility in donor phase and partitioning.
Conclusion: Trolamine salicylate exhibited less flux and diffusion coefficient through rat skin than salicylic acid due to its hydrophilic property. Partitioning from vehicle into skin was the rate-limiting step for trolamine salicylate permeability through rat skin.
Keywords: Trolamine salicylate, Percutaneous absorption, Chemical enhancers, Supersaturation technique, Differential scanning calorimetry
Tropical Journal of Pharmaceutical Research December 2010; 9 (6): 541-548
