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Improved Production of Pharmacologically-active Sclerotiorin by Penicillium sclerotiorum
Abstract
Purpose: The aim of this work was to study the optimum conditions for the production of sclerotiorin, a highly active secondary metabolite of Penicillium sclerotiorum under different cultural media. Methods: A Brazilian strain of P. sclerotiorum was grown under different culture conditions in two liquid media (malt and a dextrose-peptone salt medium supplemented with sodium chloride) and in solid state fermentation in rice. Sclerotiorin production was monitored by high performance liquid chromatography (HPLC). Results: Quantitative analysis of sclerotiorin content by HPLC indicated that sclerotiorin production reached the highest level (up to 313 + 10 mg.L-1) in the dextrose-based medium after 10 days of fermentation. Rice and malt broth showed lower production levels.
Conclusion: Enhanced production of P. sclerotiorin for pharmaceutical development can be achieved using dextrose-based cultures.
Keywords
: Penicillium sclerotiorum, Sclerotiorin,Yield improvement, HPLC, Pharmaceutical industry
